BioClinic Naturals NAC & ALA 90 Capsules Assured Natural Distribution

Feature Summary

NAC and ALA are highly complementary nutrients, critical to cellular function and mitigation of hyperglycemia-associated damage. NAC drives the synthesis of glutathione, often depleted in cardiovascular diseases and metabolic and oxidative stress conditions.^1,2 NAC also has direct antioxidant activity, restores pools of intracellular thiols, and has an anti-inflammatory effect, mediated via inhibition of nuclear factor kappa B (NF-κB).³ Glutathione is needed for the detoxification of many persistent organic pollutants, compounds known to impair mitochondrial function, adipose tissue metabolism, and pancreatic islet cell function.⁴ In addition to glutathione support, NAC enhances antioxidant protection through multiple pathways, including upregulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) activation, suggesting a significant potential to mitigate pathology due to oxidative stress.⁵ Clinical trials have shown that NAC restores intraplatelet glutathione levels in certain populations – a marker of atherothrombotic risk – reduces homocysteine, and improves endothelial function in coronary artery disease (at doses of 600–1800 mg/day).^6,7

ALA, in turn, recycles antioxidant nutrients such as vitamin C and glutathione, and is a cofactor for several mitochondrial enzymes as well as glutathione reductase.⁸ It supports glycemic control and insulin sensitivity in individuals with inadequate glucose control, endothelial function among people with impaired glucose tolerance, and weight control among obese subjects.^9,10,11 It has a well-recognized benefit for mitigating the neuronal oxidative damage resulting from hyperglycemia.^12,13 Clinical trial data has shown improvement in multiple markers of oxidative stress and vascular inflammation in a variety of populations.^14,15 Its antioxidant and neuroprotective effects may also provide protection against neurodegeneration and a range of oxidant-associated diseases.^16,17